Reports said at least 15 were killed when the car bomb exploded near a Syrian army checkpoint in the Sayeda Zeinab Shrine, south of Damascus.
Amaq news agency affiliated to the militants did not give details beyond saying the group was responsible for the bombing, the third such bombing attack this year.
Multiple explosions in February killed scores of people in the Sayeda Zeinab area, in one of the bloodiest attacks there.
A terrorist attack there less than a month earlier claimed by Daesh Takfiris killed 70 people.