The letter, published in the Guardian, is part of a day of protest on Saturday in occupied lands, Palestine and two dozen other countries over an Israeli parliamentary bill that is expected to get final approval by the end of this year.
The eviction and destruction of about 35 "unrecognised" villages in the Negev desert will, the letter says, "mean the forced displacement of Palestinians from their homes and land, and systematic discrimination and separation".
The signatories – who include the artist Antony Gormley, the actor Julie Christie, the film director Mike Leigh and the musician Brian Eno – are demanding that the British government hold Israel to account over its human rights record and obligations under international law.
According to Israel, the aims of the Prawer Plan – named after the head of a government commission, Ehud Prawer – are economic development of the Negev desert and the regulation of Palestinian Bedouins living in villages .
The population of these villages will be removed to designated towns, while plans for new Jewish settlements in the area are enacted.
But Adalah , a human rights and legal centre for Arabs in Israel, says: "The real purpose of the legislation [is] the complete and final severance of the Bedouin's historical ties to their land."
The "unrecognised" villages in the Negev, whose populations range from a few hundred to 2,000, lack basic services such as running water, electricity, landline telephones, roads, high schools and health clinics. Some consist of a few shacks and animal pens made from corrugated iron; others include concrete houses and mosques built without necessary but unobtainable permission.
The Bedouin comprise about 30% of the Negev's population but their villages take up only 2.5% of the land.
Source: The Guardian