Bayan hijirar Annabi daga Makka zuwa Madina, Umar, Abubakar, Abdulrahman bin Auf da wasu da dama sun so auren Fatima. A halin da ake ciki Sayyidina Ali (a.s) yana matukar sha'awar aurensa saboda alakar danginsa da Manzon Allah da kyawawan dabi'un Fatima. Amma a cewar masana tarihi, bai yarda da kansa ya yi wa ‘yar Annabi shawara ba. Saad bin Muaz ya isar da wannan lamari ga Annabi kuma Annabi ya yarda da shawarar Ali. Kamar sauran muhajirai, Ali (a.s.) ya fuskanci matsalar kudi a watannin farko bayan hijira, don haka ya bi shawarar Annabi sai ya sayar (ko jingina) makamansa ya sanya farashinsa a matsayin hatimin Fatimah. An gudanar da daurin auren Ali (a.s.) da Fatima (s.a.) a gaban musulmi a masallacin Annabi (s.a.w).
Zamanin farko na rayuwar Fatima (S) da Ali (A) ya kasance cikin mawuyacin hali na tattalin arziki, har a wasu lokutan ba su da abin da za su ciyar da ‘ya’yansu. Duk da wannan mawuyacin hali, Fatima (a.s) ba ta nuna adawa da halin da ake ciki ba, a wasu lokutan kuma ta kan yi ulun ulu don taimakawa mijinta. A bisa shawarar Manzon Allah (SAW) Fatimah (SAW) ta so ta yi aikin cikin gida da kanta, ta bar wa Ali (a.s) al’amura a wajen gida. Sa'ad da Feze ya aike shi gidansa bawa, ya yi rabin ayyukan gida da kansa, ya bar wa Feze sauran rabin.
Ali (a.s) ya girmama Fatima (a.s) sosai. Ya zo a cikin ruwaya daga Sayyidina Ali (a.s.) cewa ya ce ban taba fusata Fatimah ba, haka nan Fatima ba ta fusata ni ba. Majiyoyin Shi'a da Sunna sun yarda cewa Hassan da Hussein da Zainab da Ummu Kulthum 'ya'yan Fatima da Ali ne guda hudu. A madogaran Shi'a da wasu majiyoyin Sunna, an ambaci wani yaro a gare ta, wanda aka zubar da cikinsa saboda barnar da aka yi wa Fatima a cikin abubuwan da suka faru bayan Manzon Allah (SAW). An ambaci sunansa a matsayin Mohsen ko Mohsen.
Fatemeh (S) ta kasance tana da ayyukan zamantakewa da kuma matsayi na siyasa. Hijira zuwa Madina, Jiyar Manzon Allah (SAW) a lokacin yakin Uhudu, kasancewar kusa da jikin Hamza Sayyed al-Shahda tare da Safiya ‘yar uwar Hamza kuma kanwar Manzon Allah (SAW) a Uhudu, suna kai wa Manzon Allah abinci. (SAW) a yakin Khandaq da tare da shi wajen yakar Makka na daga cikin ayyukan da ya gabata na daga wafatin Manzon Allah (SAW).