An haifi Abdul Hamid bin Abdul Aziz Keshk a ranar 13 ga Zu al-Qaida shekara ta 1351, daidai da 10 ga Maris, 1933 Miladiyya a garin Shabrakhit da ke lardin Behira na kasar Masar. Tun yana yaro ya je makaranta ya haddace kur'ani mai tsarki gaba daya kafin ya kai shekaru goma, sannan ya je cibiyar addini ta Iskandariya ya samu matsayi na daya a duk fadin kasar Masar a jarrabawar karshe ta makarantar Azhar . Sannan ya shiga jami'ar Azhar. Ya kasance ƙwararren ɗalibi a tsawon karatunsa kuma ya koyar da wasu kwasa-kwasan lokacin karatunsa.
A shekarar 1957 aka zabi Abdul Hamid a matsayin malami a tsangayar addini a jami'ar Azhar dake birnin Alkahira, amma ya fi sha'awar karantarwa. Shi ya sa ya bar koyarwa a jami’a.
Ya gabatar da jawabinsa na farko a masallacin garinsu. Yana da shekara 12 a lokacin. Lokacin da shugaban masallacin bai halarta ba, sai ya yi karfin hali ya hau kan mimbari ya gayyaci jama'a domin su kiyaye adalci da tausayawa juna.
Abdul Hamid ya shiga duniyar magana a shekarar 1961 bayan ya kammala karatunsa na tsangayar ka'idojin addini da matsakaicin matsakaici da lasisin koyarwa. Ya yi karatu a masallatan Masar tsawon shekaru ashirin.
An kama shi a shekara ta 1965 saboda sukar manufofin "Gamal Abdel Nasser" (shugaban Masar tsakanin 1956 da 1970) kuma ya shafe shekaru biyu da rabi a gidan yari kuma an azabtar da shi sosai duk da makanta.
Bayan an sallame shi, ya ci gaba da gudanar da ayyukansa a masallatai, kuma tun a shekarar 1972, jawabansa suka yi ta karbuwa. Daga shekarar 1976, musamman bayan kammala yarjejeniyar "Camp David" da kuma sasantawa da Isra'ila, ya yi kakkausar suka ga Anwar Sadat (shugaban Masar tsakanin 1970 zuwa 1981) tare da zargin gwamnatin Masar da cin amanar Musulunci.
Bayan da Sadat ya yi kakkausar murya a ranar 5 ga Satumba, 1981 a majalisar dokokin Masar da kuma kai hari ga masu sukarsa, musamman malamai, Abdul Hamid Keshk na cikin wadanda aka kama tare da daure su. A wannan lokacin, ya sha azaba mai tsanani, wanda sakamakonsa ya kasance a cikin jikinsa tsawon shekaru. An saki Abdulhamid a 1982 amma an daina ba shi damar yin magana.