In a statement, Sheikh Ali al-Qaradaghi said some have plotted to split up Yemen, Anadolu Agency reported.
He added that if the issue is not addressed soon, the plot will have grave consequences.
Standing beside the Yemeni nation in these conditions and helping them get out of the current situation is a religious duty, the cleric stressed.
Saudi Arabia and a number of its regional allies launched the devastating war on Yemen in March 2015 in order to bring former president Abd Rabbuh Mansur Hadi back to power and crush the Houthi Ansarullah movement.
The US-based Armed Conflict Location and Event Data Project (ACLED), a nonprofit conflict-research organization, estimates that the war has claimed more than 100,000 lives over the past five years.
More than half of Yemen’s hospitals and clinics have been destroyed or closed during the war by the Saudi-led coalition, which is supported militarily by the UK, US and other Western nations.
At least 80 percent of the 28 million-strong population is also reliant on aid to survive in what the United Nations has called the world’s worst humanitarian crisis.